Dean P M
Diabetologia. 1976 May;12(2):111-4. doi: 10.1007/BF00428974.
The rate of formation of beta-granules in mouse islet cells has been studied by morphometry using experimental conditions in which insulin secretion is known to be blocked. The number of beta-granules in a cell is increased by 120%, 45 minutes after a continued glucose stimulus of 16.7 mM. The implications of the results are discussed with respect to the construction of kinetic models for the secretion of insulin by exocytosis.
通过形态测量法，在已知胰岛素分泌受阻的实验条件下，对小鼠胰岛细胞中β颗粒的形成速率进行了研究。在持续给予16.7 mM葡萄糖刺激45分钟后，细胞中β颗粒的数量增加了120%。结合胞吐作用分泌胰岛素的动力学模型构建，对该结果的意义进行了讨论。
