Wishart J M, Horowitz M, Morris H A, Need A G, Russo A, Jones K L, Sun W M, Nordin B E
Department of Medicine, Royal Adelaide Hospital, South Australia.
Eur J Clin Invest. 1995 Feb;25(2):123-7. doi: 10.1111/j.1365-2362.1995.tb01536.x.
The relationship between calcium absorption and gastric emptying and the precision of measurement of fractional calcium absorption using a single isotope technique were evaluated in 14 normal postmenopausal women (age range 61-72 years). On two occasions separated by between 5 and 15 days, each subject was given 250 mL water containing 0.2 MBq of 45Ca in 20 mg of calcium carrier as the chloride, 20 mg kg-1 paracetamol and 9 MBq of 99mTc sulphur colloid. Venous blood samples were taken at -2, 15, 30, 45, 60, 90, 120, 150 and 180 min after consumption of the drink, and gastric emptying (GE) was monitored with a gamma camera. Fractional calcium absorption in the first hour (alpha 6) was calculated from the blood samples obtained at 15, 30, 45, 60, 90 and 120 min. An absorption rate was also derived from the 60 min sample using only a calibration curve (alpha 1). There were close correlations between radiocalcium absorption on the two study days (r = 0.89, P < 0.001 for both alpha 1 and alpha 6) and between alpha 1 and alpha 6 (r = 0.93, P < 0.001). Plasma paracetamol concentrations at 15 min were directly related to the early phase of GE (r = 0.42, P < 0.05). In contrast, calcium absorption was inversely related to GE (r = 0.45, P < 0.05). We conclude that radiocalcium absorption is not greatly influenced by gastric emptying rate and that the single blood sample procedure has similar precision to the six-blood sample test.
在14名正常绝经后女性（年龄范围61 - 72岁）中，评估了钙吸收与胃排空之间的关系，以及使用单一同位素技术测量钙吸收分数的精确度。在间隔5至15天的两个时间段，每位受试者饮用250毫升水，其中含有0.2兆贝可的45Ca，以氯化钙形式存在于20毫克钙载体中，20毫克/千克对乙酰氨基酚以及9兆贝可的99mTc硫胶体。饮用饮料后-2、15、30、45、60、90、120、150和180分钟采集静脉血样，并用γ相机监测胃排空（GE）。根据在15、30、45、60、90和120分钟采集的血样计算第一小时的钙吸收分数（α6）。还仅使用校准曲线从60分钟的样本得出吸收速率（α1）。两个研究日的放射性钙吸收之间（α1和α6的r = 0.89，P < 0.001）以及α1和α6之间（r = 0.93，P < 0.001）存在密切相关性。15分钟时的血浆对乙酰氨基酚浓度与胃排空的早期阶段直接相关（r = 0.42，P < 0.05）。相反，钙吸收与胃排空呈负相关（r = 0.45，P < 0.05）。我们得出结论，放射性钙吸收不受胃排空速率的很大影响，并且单血样程序与六血样测试具有相似的精确度。
