关于噬菌体中顺式作用调节蛋白的性质和基因组织：以噬菌体λ的Q基因为例。
On the nature of cis-acting regulatory proteins and genetic organization in bacteriophage: the example of gene Q of bacteriophage lambda.
作者信息
Echols H, Court D, Green L
出版信息
Genetics. 1976 May;83(1):5-10. doi: 10.1093/genetics/83.1.5.
Abstract
We note the existence of a "partially cis-acting" regulatory protein of bacteriophage lambda: the product of the phage Q gene. We suggest that there may be a complete spectrum from "all cis" to "all trans" for such regulatory proteins. This behavior might arise because a DNA-binding protein either acts at a nearby (cis) site soon after synthesis or becomes "lost" for its trans activity on another genome through nonspecific interactions with DNA. Our proposed explanation provides one evolutionary basis for the linkage of genes for regulatory proteins and the sites at which such proteins act; it also suggests a possible rationale for the "metabolic instability" of certain regulatory proteins.
摘要
我们注意到噬菌体λ存在一种“部分顺式作用”的调节蛋白：噬菌体Q基因的产物。我们认为，此类调节蛋白可能存在从“全顺式”到“全反式”的完整谱系。这种行为可能是因为一种DNA结合蛋白在合成后不久就在附近（顺式）位点起作用，或者由于与DNA的非特异性相互作用而在另一个基因组上失去其反式活性。我们提出的解释为调节蛋白基因与其作用位点的连锁提供了一种进化基础；它还为某些调节蛋白的“代谢不稳定性”提供了一种可能的基本原理。
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