Nair C K, Pradhan D S
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Mar;29(3):235-40. doi: 10.1080/09553007614550261.
The presence of iodoacetic acid (IAA, 10(4) M) during exposure of Escherichia coli cells to 25 krad gamma-radiation under anoxia resulted in a greater number of radiation-induced single-strand scissions in DNA. The single-strand breaks produced under oxic conditions of irradiation, however, were only marginally increased when IAA was present during irradiation. Although cells irradiated under anoxic or oxic condition and those irradiated under anoxic condition in the presence of IAA were capable of rejoining single-strand breaks produced in DNA, those irradiated under oxic condition in the presence of IAA had lost this capacity.
在缺氧条件下，将大肠杆菌细胞暴露于25千拉德的γ辐射时，加入碘乙酸（IAA，10⁻⁴ M）会导致DNA中辐射诱导的单链断裂数量增加。然而，在有氧辐射条件下产生的单链断裂，在辐射期间加入IAA时仅略有增加。尽管在缺氧或有氧条件下辐照的细胞以及在缺氧条件下辐照且存在IAA的细胞能够修复DNA中产生的单链断裂，但在有氧条件下辐照且存在IAA的细胞已失去这种能力。
