Pometkin V V, Nikonova T V, Brykova S V
Probl Endokrinol (Mosk). 1994 Nov-Dec;40(6):5-7.
Fifty-two patients with type I diabetes mellitus were examined. The patients were divided into 4 groups with various duration of the disease: group 1 included patients with the newly diagnosed disease, group 2 those with disease standing of 1 to 5 years, group 3 were patients suffering from diabetes for 6 to 10 years, and group 4 were diabetics for 10 years and more. The parameters examined were antibodies to surface antigens of islet cells, absolute and relative counts of T and B lymphocytes in the peripheral blood, counts of T- helpers and T-suppressors and cytotoxic cells and their ratios, counts of natural killers, DR (+) and JgG (+) cells, and basal C-peptide level. The results showed a correlation between autoantibodies to surface antigens of islet cells and the count of B lymphocytes, an inversion of T lymphocyte subpopulations, with the helper/suppressor index increased at the initial stages of the disease and decreasing with the disease progress.
对52例I型糖尿病患者进行了检查。这些患者根据病程长短分为4组：第1组包括新诊断出疾病的患者，第2组为病程1至5年的患者，第3组是患糖尿病6至10年的患者，第4组是患糖尿病10年及以上的患者。所检测的参数包括胰岛细胞表面抗原抗体、外周血中T和B淋巴细胞的绝对计数和相对计数、辅助性T细胞、抑制性T细胞和细胞毒性细胞的计数及其比例、自然杀伤细胞计数、DR(+)和JgG(+)细胞计数以及基础C肽水平。结果显示，胰岛细胞表面抗原自身抗体与B淋巴细胞计数之间存在相关性，T淋巴细胞亚群出现倒置，在疾病初期辅助/抑制指数升高，随疾病进展而降低。
