Lauby V, Imbert B, Eysseric H, Dufrêne I, Mallaret M
Centre régional de pharmacovigilance, CHU de Grenoble, France.
Rev Med Interne. 1995;16(3):212-3. doi: 10.1016/0248-8663(96)80694-1.
We report the two first cases of neuropsychic side-effects with zipeprol (non opiate antitussive) given at therapeutic doses. In both cases, the patients showed confusion, whereas, hallucinations occurred only in one case. The anticholinergic activity of zipeprol might explain these effects. These two cases are in agreement with zipeprol central nervous system action.
我们报告了两例使用治疗剂量的齐哌丙醇（非阿片类镇咳药）出现神经精神副作用的首例病例。在这两例病例中，患者均出现了意识模糊，而幻觉仅在其中一例中出现。齐哌丙醇的抗胆碱能活性可能解释了这些效应。这两例病例与齐哌丙醇对中枢神经系统的作用相符。
