Werth B, Kuhn M, Hartmann K, Reinhart W H
Medizinische Klinik, Kantonsspital Chur.
Schweiz Med Wochenschr. 1995 Apr 15;125(15):731-4.
Acute pancreatitis may be caused by a number of different drugs. However, reports on the frequency of drug-related acute pancreatitis and on the drugs involved are rare. We therefore investigated all cases of drug-related acute pancreatitis which had been reported to the Swiss Drug Monitoring Center (Schweizerische Arzneimittel-Nebenwirkungszentrale, SANZ) between 1981 and 1993. During this period the total number of reported adverse drug reactions was 7338, 20 of which (0.3%) were considered to be probable cases of drug-related pancreatitis. In 18 cases a single drug was incriminated, whereas in two cases two and four drugs respectively had to be investigated. Serious courses, deaths, or chronic pancreatitis were not reported. The most frequent single drugs incriminated were sulfonamide derivatives (5 cases), valproic acid (3 cases) and nonsteroidal anti-flammatory drugs (2 cases). The frequencies reported here are consistent with the literature. Considering the total number of drugs prescribed, acute pancreatitis is a rare adverse drug reaction.
急性胰腺炎可能由多种不同药物引起。然而，关于药物相关性急性胰腺炎的发生率以及所涉药物的报道却很少。因此，我们调查了1981年至1993年间向瑞士药物监测中心（Schweizerische Arzneimittel-Nebenwirkungszentrale, SANZ）报告的所有药物相关性急性胰腺炎病例。在此期间，报告的药物不良反应总数为7338例，其中20例（0.3%）被认为可能是药物相关性胰腺炎病例。18例中涉及单一药物，而在另外两例中，分别有两种和四种药物需要调查。未报告严重病程、死亡或慢性胰腺炎病例。最常涉及的单一药物是磺胺类衍生物（5例）、丙戊酸（3例）和非甾体抗炎药（2例）。此处报告的发生率与文献一致。考虑到所开药物的总数，急性胰腺炎是一种罕见的药物不良反应。
