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止血带充气后时间间隔对头孢菌素组织浓度的影响。在充气前20分钟给药可达到最高水平。

Effect of time interval on tissue concentrations of cephalosporins after tourniquet inflation. Highest levels achieved by administration 20 minutes before inflation.

作者信息

Dounis E, Tsourvakas S, Kalivas L, Giamaçellou H

机构信息

Department of Orthopedics, Laiko General Hospital, Athens, Greece.

出版信息

Acta Orthop Scand. 1995 Apr;66(2):158-60. doi: 10.3109/17453679508995512.

DOI:10.3109/17453679508995512
PMID:7740948
Abstract

We studied the effect of different time intervals between antibiotic administration and tourniquet inflation in 62 patients undergoing reconstructive surgery in the lower extremities. The in vivo concentrations in soft tissue and bone of 3 cephalosporins (ceftazidime, ceftriaxone and ceforanide) were determined. Our findings suggest that the highest tissue concentrations were achieved by administration 20 min before tourniquet inflation.

摘要

我们研究了62例接受下肢重建手术的患者中，抗生素给药与止血带充气之间不同时间间隔的影响。测定了3种头孢菌素（头孢他啶、头孢曲松和头孢尼西）在软组织和骨骼中的体内浓度。我们的研究结果表明，在止血带充气前20分钟给药可达到最高组织浓度。

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