Ferrara A, Stortini G, Bellussi L, Di Girolamo S, Zuccarini N, Passali D
Insegnamento di Fisiopatologia Respiratoria, Università degli Studi di Siena.
Acta Otorhinolaryngol Ital. 1994 Nov-Dec;14(6):633-42.
Study aimed principally at applying the data recently gathered with regard to Bronchial Reactivity to rhinology, with special regard to non-atopic or allergic hyperresponsiveness. In the past decade, Ultrasonic Nebulized Distilled Water (U.N.D.W.) was recognized as one of the best test in Bronchial Reactivity. In allergic and non-allergic rhinitis, the Authors tried to use U.N.D.W. to reproduce symptoms of rhinitis. Results show that U.N.D.W. could be included in the Nasal Hyperreactivity test. Secondly, but not less interesting, is the prevention of experimental rhinitis with U.N.D.W. by using Furosemide, a diuretic administered by inhalation. The prevention of Ca++ penetration into nasal cell can block any mediator-activation. Such procedure may be applied in polyposis after surgery in order to prevention recurrence, data show the complete applicability of this pharmacological treatment in children as well.
该研究主要旨在将最近收集的有关支气管反应性的数据应用于鼻科学，特别关注非特应性或过敏性高反应性。在过去十年中，超声雾化蒸馏水（U.N.D.W.）被认为是支气管反应性测试中最好的测试之一。在变应性和非变应性鼻炎中，作者试图使用U.N.D.W.来重现鼻炎症状。结果表明，U.N.D.W.可纳入鼻高反应性测试。其次，但同样有趣的是，通过吸入使用利尿剂速尿，用U.N.D.W.预防实验性鼻炎。阻止钙离子进入鼻细胞可阻断任何介质激活。这种方法可用于息肉切除术后预防复发，数据表明这种药物治疗在儿童中也完全适用。
