Passali D, Bellussi L, Lauriello M, Ferrara A
Istituto di Discipline Otroinolaringologiche, Università di Siena.
Acta Otorhinolaryngol Ital. 1995 Apr;15(2):91-100.
Nowadays nasal polyposis must be still considered an unsolved problem as the surgical procedures are unable to treat this pathology and the recurrence is very common. For this reason several Authors starting from the pathogenesis and the histological features have chosen a medical point of view at the aim of preventing the natural course of this disease. The present study experimented the effect of the furosemide locally administered in the prevention of polyps relapsing in subjects previously operated on. The Authors pointed out that the furosemide was able to decrease the nasal reactivity to the challenge with ultrasonic nebulized distilled water. Besides this drug locally administered for 3 months (once a day) maintained the nasal mucosa of the patients affected with hyperreactivity in a good functional condition without nasal obstruction. In fact no polyps were found at the objective examinations performed during the three years follow up and the values of acoustic rhinometry measurements were within the normal range. Finally the present research gave the opportunity to hypothesize the role of sodium, potassium and calcium ions transport regulated by drugs or other physiopathological events, in the physiology of the nasal mucosa.
如今，鼻息肉病仍被视为一个尚未解决的问题，因为手术程序无法治疗这种病症，而且复发非常常见。因此，一些作者从发病机制和组织学特征出发，选择了医学视角，旨在预防这种疾病的自然发展过程。本研究试验了局部应用速尿在预防先前接受过手术的患者息肉复发方面的效果。作者指出，速尿能够降低鼻腔对超声雾化蒸馏水激发的反应性。此外，这种药物局部应用3个月（每天一次）可使患有高反应性的患者鼻腔黏膜保持良好的功能状态，且无鼻塞。事实上，在三年随访期间进行的客观检查中未发现息肉，鼻声反射测量值也在正常范围内。最后，本研究为推测药物或其他生理病理事件调节的钠、钾和钙离子转运在鼻腔黏膜生理学中的作用提供了机会。
