Chantler E, Kenway P, Larouk Z, Faragher E B, Morris J, Kosonen A, Allonen H, Elstein M
Department of Obstetrics and Gynaecology, University Hospital of South Manchester, West Didsbury, UK.
Adv Contracept. 1994 Dec;10(4):287-301. doi: 10.1007/BF01984126.
To measure the copper from Nova-T IUDs that have been used for up to 9 years. To examine the composition and extent of surface deposits on these used IUDs.
Nova-T IUDs were randomly collected at normal replacement or removal. The copper, silver and calcium content was quantified by X-ray fluorescence; surface topography and analysis was by scanning electron microscopy and X-ray dispersive analysis.
Copper loss slowly increased at an exponential rate over the study period but the copper was stabilized by the silver core and did not show increased fragmentation with extended use. No corrosion of the silver core was detected. Calcium- and sulfur-containing surface deposits built up on the copper but did not modify the rate of copper release.
The mean rate of copper loss was 0.25 mumol/day during the first 40 months of use, which is not significantly different from that of similar IUDs without a silver core. The silver core of the copper coil on the Nova-T IUD prevented its fragmentation. Surface deposits containing calcium and sulfur that built up on the IUD did not affect the rate of copper loss.
测量使用长达9年的Nova-T宫内节育器（IUD）中的铜含量。检查这些使用过的IUD表面沉积物的组成和程度。
在正常更换或取出时随机收集Nova-T IUD。通过X射线荧光定量铜、银和钙含量；通过扫描电子显微镜和X射线色散分析进行表面形貌和分析。
在研究期间，铜损失以指数速率缓慢增加，但铜被银芯稳定，并且未显示随着使用时间延长而破碎增加。未检测到银芯腐蚀。含铜表面形成了含钙和硫的沉积物，但未改变铜释放速率。
在使用的前40个月中，铜损失的平均速率为0.25微摩尔/天，这与没有银芯的类似IUD的速率没有显著差异。Nova-T IUD上铜线圈的银芯防止其破碎。IUD上形成的含钙和硫的表面沉积物不影响铜损失速率。
