Suzuki M, Itoh H, Sugiyama K, Takagi I, Nishimura J, Kato K, Mamiya S, Baba S, Ohya Y, Itoh H
Department of Otorhinolaryngology, Nagoya City University Medical School, Japan.
Allergy. 1995 Jan;50(1):23-7. doi: 10.1111/j.1398-9995.1995.tb02479.x.
To determine the importance of silkworm moth allergens, we tested 267 patients with allergic rhinitis with CAP-RAST, a new assay system for detecting specific IgE in sera. We used the following allergen sources: house-dust mite, Candida, Alternaria, cat dander, orchard grass, ragweed, mugwort, Japanese hops, Japanese cedar, Japanese cypress, cotton, silk, larval chironomid midge, adult chironomid midge, and silkworm moth. As expected, the highest positive rate of reaction, as determined by CAP-RAST, was 73.8% for Japanese cedar, followed by 53.2% for mite and 50.6% for Japanese cypress. Although the positive rate for silkworm moth was not as high as for cedar pollen, one-third of patients had specific IgE against silkworm moth. The positive rate of reaction to silkworm moth was much higher than that to chironomid. It was interesting to note that the patients reported had not been documented as having frequent contact with silkworm moth allergen. Correlations between silkworm moth and silk, and silkworm moth and chironomid midge were found to be significant (P < 0.001). Silkworm moth allergen showed the third highest reaction rate in patients with severe symptoms. These results suggest that silkworm moth allergen should be considered to be important in patients with allergic rhinitis in Japan.
为了确定家蚕蛾过敏原的重要性，我们使用一种检测血清中特异性IgE的新检测系统——CAP-RAST，对267例过敏性鼻炎患者进行了检测。我们使用了以下过敏原来源：屋尘螨、念珠菌、链格孢属、猫毛屑、果园草、豚草、艾蒿、啤酒花、日本柳杉、日本扁柏、棉花、丝绸、摇蚊幼虫、摇蚊成虫和家蚕蛾。正如预期的那样，通过CAP-RAST测定，反应阳性率最高的是日本柳杉，为73.8%，其次是螨，为53.2%，日本扁柏为50.6%。虽然家蚕蛾的阳性率不如雪松花粉高，但三分之一的患者对家蚕蛾有特异性IgE。家蚕蛾的反应阳性率远高于摇蚊。值得注意的是，所报告的患者并未被记录为经常接触家蚕蛾过敏原。发现家蚕蛾与丝绸以及家蚕蛾与摇蚊之间存在显著相关性（P < 0.001）。在家蚕蛾过敏原在症状严重的患者中显示出第三高的反应率。这些结果表明，家蚕蛾过敏原在日本过敏性鼻炎患者中应被视为重要因素。
