Apfelbaum J D, Caravati E M, Kerns W P, Bossart P J, Larsen G
Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, USA.
Ann Emerg Med. 1995 May;25(5):631-5. doi: 10.1016/s0196-0644(95)70176-1.
To evaluate the cardiovascular effects of carbamazepine in patients presenting to the emergency department.
A retrospective case series from February 1, 1985, to July 30, 1993.
Six urban EDs.
Seventy-two adult and pediatric patients with serum carbamazepine concentrations greater than 12 micrograms/mL and concurrent 12-lead ECGs.
The mean carbamazepine level was 24 micrograms/mL (range, 12.6 to 55 micrograms/mL). Minor ECG abnormalities were noted but no clinically significant arrhythmias were found. No correlation was found between carbamazepine concentration and heart rate or PR, QRS, or corrected QT intervals. Four adult patients had transient hypotension.
Clinically significant cardiovascular toxicity occurs rarely in patients with toxic carbamazepine concentrations. ECG findings do not correlate with serum carbamazepine concentration.
评估卡马西平对急诊患者心血管系统的影响。
一项回顾性病例系列研究，时间跨度为1985年2月1日至1993年7月30日。
六家城市急诊科。
72例成年和儿科患者，其血清卡马西平浓度大于12微克/毫升，并同时进行了12导联心电图检查。
卡马西平平均水平为24微克/毫升（范围为12.6至55微克/毫升）。记录到轻微的心电图异常，但未发现具有临床意义的心律失常。未发现卡马西平浓度与心率或PR、QRS或校正QT间期之间存在相关性。四名成年患者出现短暂性低血压。
卡马西平浓度中毒的患者很少发生具有临床意义的心血管毒性。心电图表现与血清卡马西平浓度无关。
