Yamada H, Nagaoka I, Takamori K, Ogawa H
Department of Dermatology, International Goodwill Hospital, Yokohama, Japan.
Artif Organs. 1995 Jan;19(1):98-102. doi: 10.1111/j.1525-1594.1995.tb02253.x.
The patient, a 32-year-old male, was diagnosed as having hyperimmunoglobulin E syndrome and was subsequently treated with double filtration plasmapheresis (DFPP). The patient showed a defective chemotaxis with reference to polymorphonuclear leukocytes and the presence of chemotactic inhibitor in his serum. By the fifth treatment with DFPP, chemotactic responses had improved, and there was no further evidence of chemotactic inhibitor in his serum. These findings suggest that the patient's chemotactic responses improved as a result of the removal or decrease in chemotactic inhibitor in his serum upon treatment with DFPP. Accordingly DFPP may be an effective treatment for hyperimmunoglobulin E syndrome.
该患者为一名32岁男性，被诊断患有高免疫球蛋白E综合征，随后接受了双重过滤血浆置换（DFPP）治疗。该患者的多形核白细胞趋化性存在缺陷，且其血清中存在趋化抑制剂。至DFPP治疗第五次时，趋化反应有所改善，且其血清中不再有趋化抑制剂的证据。这些发现表明，该患者的趋化反应因DFPP治疗后血清中趋化抑制剂的清除或减少而得到改善。因此，DFPP可能是治疗高免疫球蛋白E综合征的一种有效疗法。
