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1
Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.血小板衍生生长因子-BB和转化生长因子-β1对透明质酸生物合成的刺激涉及蛋白激酶C的激活。
Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):817-21. doi: 10.1042/bj3070817.
2
Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration.血小板衍生生长因子-BB、胰岛素样生长因子-I和佛波酯激活不同的信号通路以刺激血管平滑肌细胞迁移。
Exp Cell Res. 1998 Aug 1;242(2):548-60. doi: 10.1006/excr.1998.4138.
3
PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase.血小板衍生生长因子诱导的糖胺聚糖合成是通过磷脂酰肌醇3激酶介导的。
Am J Physiol. 1998 May;274(5):L702-13. doi: 10.1152/ajplung.1998.274.5.L702.
4
Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells.血小板衍生生长因子激活人间皮细胞中透明质酸合成酶的分子机制研究
Biochem J. 1992 Apr 1;283 ( Pt 1)(Pt 1):165-70. doi: 10.1042/bj2830165.
5
Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis.血管平滑肌细胞中血小板衍生生长因子（PDGF）α受体和β受体之间信号转导的差异。血小板衍生生长因子BB（PDGF-BB）是一种有效的促有丝分裂原，但血小板衍生生长因子AA（PDGF-AA）仅促进蛋白质合成而不激活DNA合成。
J Biol Chem. 1994 Dec 2;269(48):30546-52.
6
Platelet-derived growth factor stimulates sodium-dependent Pi transport in osteoblastic cells via phospholipase Cgamma and phosphatidylinositol 3' -kinase.血小板衍生生长因子通过磷脂酶Cγ和磷脂酰肌醇3'-激酶刺激成骨细胞中钠依赖性磷酸盐转运。
J Bone Miner Res. 1997 Jan;12(1):36-44. doi: 10.1359/jbmr.1997.12.1.36.
7
Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts.磷脂酶D和α/β-蛋白激酶C在C3H10T1/2成纤维细胞生长因子诱导信号传导中的作用
Biochim Biophys Acta. 2003 Jun 10;1632(1-3):62-71. doi: 10.1016/s1388-1981(03)00063-5.
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EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.EJ-Ras通过磷脂酰肌醇3激酶抑制磷脂酶Cγ1，但不抑制血小板衍生生长因子-BB诱导的肌动蛋白聚合。
Circ Res. 1996 Feb;78(2):312-21. doi: 10.1161/01.res.78.2.312.
9
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.生长因子对人真皮成纤维细胞透明质酸合成与降解的调节：透明质酸对血小板衍生生长因子BB促有丝分裂反应的重要性
Biochem J. 2007 Jun 1;404(2):327-36. doi: 10.1042/BJ20061757.
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Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy.甲磺酸伊马替尼和AMN107抑制眼眶成纤维细胞中的血小板衍生生长因子信号传导：一种治疗格雷夫斯眼病的潜在方法。
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3091-8. doi: 10.1167/iovs.08-2443. Epub 2009 Feb 21.

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Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx.树突状细胞进入淋巴管是由 CD44 和透明质酸糖萼协调的。
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The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.去泛素化酶USP4和USP17作用于透明质酸合酶2，并对其功能产生不同影响。
Oncogenesis. 2017 Jun 12;6(6):e348. doi: 10.1038/oncsis.2017.45.
6
Biology and biotechnology of hyaluronan.透明质酸的生物学与生物技术
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The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases.在生理条件下，老年人体纤维细胞中透明质酸的分泌减少主要与透明质酸合酶的下调表达有关，而与透明质酸酶的表达水平无关。
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Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).透明质酸合酶 2（HAS2）通过抑制组织金属蛋白酶抑制剂 1（TIMP-1）促进乳腺癌细胞侵袭。
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本文引用的文献

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Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1.血小板衍生生长因子受体C末端的磷酸化位点结合磷脂酶Cγ1。
Mol Biol Cell. 1993 Jan;4(1):49-57. doi: 10.1091/mbc.4.1.49.
2
Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts.人恶性间皮瘤细胞产生刺激间皮细胞和成纤维细胞产生透明质酸的因子。
Cancer Res. 1993 Jan 15;53(2):388-92.
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Receptors for transforming growth factor-beta.转化生长因子-β受体
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Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.由血小板衍生生长因子β受体转导的膜 ruffling 和趋化性需要磷脂酰肌醇3'激酶的结合位点。
Oncogene. 1994 Feb;9(2):651-60.
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Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.蛋白激酶A通过丝裂原活化蛋白激酶拮抗人动脉平滑肌细胞中血小板衍生生长因子诱导的信号传导。
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10300-4. doi: 10.1073/pnas.90.21.10300.
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Hyaluronan-binding proteins in development, tissue homeostasis, and disease.发育、组织稳态及疾病中的透明质酸结合蛋白
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Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells.透明质酸受体在人恶性间皮瘤细胞上表达，但在正常间皮细胞上不表达。
Cancer Res. 1994 Aug 15;54(16):4516-23.
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Synthesis of hyaluronate in differentiated teratocarcinoma cells. Mechanism of chain growth.分化型畸胎瘤细胞中透明质酸的合成。链增长机制。
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Synthesis of hyaluronate in differentiated teratocarcinoma cells. Characterization of the synthase.分化型畸胎瘤细胞中透明质酸的合成。合成酶的特性
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10
Interaction of hyaluronate with the surface of simian virus 40-transformed 3T3 cells: aggregation and binding studies.透明质酸盐与猿猴病毒40转化的3T3细胞表面的相互作用：聚集和结合研究。
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血小板衍生生长因子-BB和转化生长因子-β1对透明质酸生物合成的刺激涉及蛋白激酶C的激活。

Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.

作者信息

Suzuki M, Asplund T, Yamashita H, Heldin C H, Heldin P

机构信息

Department of Medical and Physiological Chemistry, Uppsala University, Sweden.

出版信息

Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):817-21. doi: 10.1042/bj3070817.

DOI:10.1042/bj3070817
PMID:7741713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1136722/
Abstract

The intracellular signal transduction pathways that mediate the stimulatory effects of platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-beta on hyaluronan biosynthesis in human fibroblasts were investigated. The stimulatory effects of both PDGF-BB and TGF-beta 1 were dependent on protein kinase C (PKC), since the PKC inhibitor calphostin C inhibited the stimulation by the growth factors. Direct activation of PKC by phorbol 12-myristate 13-acetate (PMA) also stimulated hyaluronan production, and the combination of either PDGF-BB or TGF-beta 1 and PMA gave an increased effect. One possible mechanism for activation of PKC is via induction of phospholipase C (PLC) activity; U-17322, an inhibitor of PLC-gamma, was found to inhibit partially PDGF-BB-stimulated hyaluronan synthesis. PDGF-BB is known to activate PLC-gamma through tyrosine phosphorylation; however, a PDGF beta-receptor mutant unable to interact with and activate PLC-gamma was still able to mediate induction of hyaluronan biosynthesis, indicating that PDGF-mediated stimulation is not entirely dependent on PLC-gamma. The stimulations by PDGF-BB and TGF-beta 1 were partly dependent on protein synthesis, since parts of the effects were inhibited by cycloheximide; in contrast, the effects mediated by PMA were not. Our results indicate that PKC is involved in the transduction of the effects of growth factors on hyaluronan biosynthesis, and that the effects involve direct or indirect activation of existing hyaluronan synthetase molecules, as well as induction of new enzyme molecules.

摘要

研究了介导血小板衍生生长因子（PDGF）-BB和转化生长因子（TGF）-β对人成纤维细胞透明质酸生物合成刺激作用的细胞内信号转导途径。PDGF-BB和TGF-β1的刺激作用均依赖于蛋白激酶C（PKC），因为PKC抑制剂钙泊三醇C可抑制生长因子的刺激作用。佛波酯12-肉豆蔻酸酯13-乙酸酯（PMA）直接激活PKC也可刺激透明质酸的产生，并且PDGF-BB或TGF-β1与PMA联合使用可产生增强的效果。激活PKC的一种可能机制是通过诱导磷脂酶C（PLC）活性；发现PLC-γ抑制剂U-17322可部分抑制PDGF-BB刺激的透明质酸合成。已知PDGF-BB通过酪氨酸磷酸化激活PLC-γ；然而，一种无法与PLC-γ相互作用并激活PLC-γ的PDGFβ受体突变体仍能够介导透明质酸生物合成的诱导，这表明PDGF介导的刺激并不完全依赖于PLC-γ。PDGF-BB和TGF-β1的刺激部分依赖于蛋白质合成，因为部分作用被放线菌酮抑制；相比之下，PMA介导的作用则不然。我们的结果表明，PKC参与了生长因子对透明质酸生物合成作用的转导，并且这些作用涉及现有透明质酸合成酶分子的直接或间接激活，以及新酶分子的诱导。