Koller M E, Husby P
Department of Anaesthesiology, Haukeland Sykehus, University of Bergen, Norway.
Acta Anaesthesiol Scand. 1993 Jul;37(5):465-8. doi: 10.1111/j.1399-6576.1993.tb03747.x.
Endotracheal intubation conditions 60 s after intravenous administration of either high-dose vecuronium (0.3 mg kg -1; n = 25) or suxamethonium (1.0 mg kg -1; n = 25) were compared in a blind, randomised study. No significant differences were found between the two drugs. In 96% of the patients intubation conditions were characterized as excellent or good. In only one patient (4%) in each group were intubation conditions unsatisfactory. According to our findings, high-dose vecuronium provides satisfactory intubation conditions after 60 s and may be used instead of suxamethonium for rapid sequence intubation when a long duration of neuromuscular blockade is acceptable.
在一项双盲随机研究中，比较了静脉注射大剂量维库溴铵（0.3mg/kg；n = 25）或琥珀胆碱（1.0mg/kg；n = 25）60秒后的气管插管条件。两种药物之间未发现显著差异。96%的患者插管条件为优或良。每组仅1例患者（4%）插管条件不满意。根据我们的研究结果，大剂量维库溴铵在60秒后可提供满意的插管条件，当神经肌肉阻滞持续时间可接受时，可用于快速顺序诱导插管以替代琥珀胆碱。
