Schalck R, Unternaehrer S, Gagneur D, Cerfon J F, Loeb J P
Ann Fr Anesth Reanim. 1987;6(3):169-72. doi: 10.1016/s0750-7658(87)80075-8.
Different protocols based on the priming principle have been proposed so as to enable rapid tracheal intubation with vecuronium. The conditions of such an intubation have been assessed in 47 ASA I or ASA II patients, with an empty stomach, using a priming dose of 0.01 mg X kg-1, followed by a second injection of 0.1 mg X kg-1 after a short interval of 4 min. An intubation score was defined using a nerve stimulator (Relaxograph Datex), by measuring the twitch in comparison with a reference value, as well as time before intubation for four groups of patients. Good intubation scores with a twitch approaching 50% was obtained in all and, in the same way, for a fifth group of patients, intubated in an arbitrary manner 60 s after the second dose of vecuronium. These results can be compared with those obtained by other authors using a different protocol. Nevertheless, this method does not match perfectly that of suxamethonium. Taking into account the side-effects and above all the inhalation risk existing after a priming dose, is it opportune to use this technique for the anaesthesia of a patient with a full stomach?
为了能够使用维库溴铵实现快速气管插管，人们提出了基于预注原则的不同方案。已对47例空腹的ASA I级或ASA II级患者使用0.01 mg/kg的预注剂量，然后在间隔4分钟的短时间后再注射0.1 mg/kg，评估了这种插管的条件。使用神经刺激器（Datex Relaxograph），通过与参考值比较测量抽搐以及四组患者插管前的时间来定义插管评分。所有患者均获得了接近50%抽搐的良好插管评分，同样，对于第五组患者，在第二次注射维库溴铵60秒后以任意方式进行插管。这些结果可以与其他作者使用不同方案获得的结果进行比较。然而，这种方法与琥珀胆碱的方法并不完全匹配。考虑到预注剂量后的副作用，尤其是吸入风险，对饱腹患者使用这种技术进行麻醉是否合适呢？
