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Kringle-dependent structural and functional polymorphism of apolipoprotein (a).

作者信息

Scanu A M, Edelstein C

机构信息

Department of Medicine, University of Chicago, IL 60637, USA.

出版信息

Biochim Biophys Acta. 1995 Apr 28;1256(1):1-12. doi: 10.1016/0005-2760(95)00012-2.

DOI:10.1016/0005-2760(95)00012-2
PMID:7742349
Abstract
摘要

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Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts.天然存在的人纤溶酶原，如同基因相关的载脂蛋白(a)一样，含有氧化磷脂酰胆碱加合物。
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Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.糖蛋白非转移性黑色素瘤蛋白 b，一种黑素细胞标志物，是一种黑素小体特异性和蛋白水解释放的蛋白。
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The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.
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The oxidized phospholipids linked to human apolipoprotein(a) do not derive from circulating low-density lipoproteins and are probably of cellular origin.与人类载脂蛋白(a)相关的氧化磷脂并非源自循环中的低密度脂蛋白，可能起源于细胞。
FASEB J. 2009 Mar;23(3):950-6. doi: 10.1096/fj.08-122002. Epub 2008 Nov 10.
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Protein Sci. 2001 Jun;10(6):1124-9. doi: 10.1110/ps.01701.
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Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes.载脂蛋白(a)的纤维蛋白原结合结构域位于kringle IV-10赖氨酸结合位点之外的证据：一项涉及天然存在的赖氨酸结合缺陷脂蛋白(a)表型的研究。
J Clin Invest. 1996 Jul 1;98(1):185-91. doi: 10.1172/JCI118765.