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Humoral and cell-mediated immune responses in healthy children after one or two doses of varicella vaccine.

作者信息

Watson B, Boardman C, Laufer D, Piercy S, Tustin N, Olaleye D, Cnaan A, Starr S E

机构信息

Division of Allergy, Immunology, and Infectious Diseases, Joseph Stokes, Jr., Research Institute, Philadelphia, Pennsylvania, USA.

出版信息

Clin Infect Dis. 1995 Feb;20(2):316-9. doi: 10.1093/clinids/20.2.316.

DOI:10.1093/clinids/20.2.316
PMID:7742436
Abstract

This study compared the immune responses of healthy children to one or two doses of Oka/Merck varicella vaccine. Both cell-mediated and humoral immune responses were significantly stronger 1 year later among children given two doses 3 months apart than among those given a single dose. Long-term follow-up studies are needed to determine whether two doses of vaccine indeed provide more complete and more durable protection than a single dose against breakthrough varicella in healthy children.

摘要

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