Mayberry R M, Branch P T
Centers for Disease Control, Atlanta, Georgia, USA.
Ethn Dis. 1994 Winter;4(1):41-6.
Studies of risk factor differences between racial and ethnic groups within a population may be most valuable in delineating the etiology of breast cancer. Most studies of breast cancer risk factors have been conducted only among white women. We could not find any epidemiologic studies that investigated risk factors for breast cancer occurrence among Hispanic women. The Cancer and Steroid Hormone Study provided the opportunity to investigate risk factors for breast cancer among Hispanic women aged 20 to 54 years in a population-based case-control study of 148 case and 167 control subjects. The final multiple logistic regression analysis indicated that women who had a first-degree relative (mother or sister) with breast cancer were nearly twice as likely to have had breast cancer compared to women with no family history (OR = 1.89; 95% CI 1.10-3.16). Expected patterns of association between breast cancer and number of full-term pregnancies, age at first full-term birth, and benign breast disease, although not statistically significant, were observed. Unexpectedly, the results also suggested a reduced risk of breast cancer among Hispanic women associated with early age at menarche. These factors require further evaluation in larger studies among specific Hispanic subgroups.
对人群中不同种族和族裔群体之间风险因素差异的研究，在阐明乳腺癌病因方面可能最具价值。大多数乳腺癌风险因素研究仅在白人女性中进行。我们找不到任何调查西班牙裔女性乳腺癌发生风险因素的流行病学研究。癌症与类固醇激素研究提供了一个机会，在一项基于人群的病例对照研究中，对148例病例和167名对照对象进行调查，以研究20至54岁西班牙裔女性的乳腺癌风险因素。最终的多元逻辑回归分析表明，有乳腺癌一级亲属（母亲或姐妹）的女性患乳腺癌的可能性几乎是无家族史女性的两倍（比值比=1.89；95%置信区间1.10-3.16）。观察到了乳腺癌与足月妊娠次数、首次足月分娩年龄和良性乳腺疾病之间预期的关联模式，尽管无统计学意义。出乎意料的是，结果还表明，初潮年龄较早的西班牙裔女性患乳腺癌的风险降低。这些因素需要在针对特定西班牙裔亚组的更大规模研究中进一步评估。
