Kojima M, Nakamura S, Kurabayashi Y, Shimizu K, Hosomura Y, Ohno Y, Itoh H, Yoshida K, Sano T, Sakurai S
Department of Pathology, Ashikaga Red Cross Hospital, Japan.
Pathol Int. 1995 Feb;45(2):123-30. doi: 10.1111/j.1440-1827.1995.tb03432.x.
Clinicopathologic and immunohistochemical features in 39 cases of primary intestinal non-Hodgkin's lymphoma (NHL) in Japanese patients were studied. Only resection materials in state IE and IIE-1 were included in this study because of the certainty that the intestine was the primary site of the lymphoma. The updated Kiel classification was used to classify NHL. Histologically, only two cases (5.1%) were follicular lymphomas, and the others were diffuse lymphomas. Twenty-eight patients (71.8%) had high-grade NHL and 11 (28.2%) had low-grade NHL. Twenty (71.4%) of the 28 high-grade NHL were centroblastic lymphomas, and 14 (70.0%) of these 20 cases of centroblastic lymphoma were the polymorphic variant. Ten (90.9%) of the 11 low-grade NHL were low-grade mucosa-associated lymphoid tissue (MALT) lymphomas. Macroscopically, 18 patients had polypoid masses, 17 ulcerative tumors and four had diffusely infiltrating NHL. Seven of the 10 low-grade MALT lymphomas were polypoid masses. Immunohistochemically, 35 lesions (89.7%) were of the B cell phenotype and three (7.7%) were of the T cell phenotype. In the remaining case, the cell lineage could not be determined. No lesions were considered to be of histiocytic origin. The 5 year survival rate for high-grade B cell lymphomas was poorer than for low-grade B cell lymphomas, and the present study indicated that the histological grade of the intestinal B cell lymphomas was a prognostically significant factor.
对39例日本原发性肠道非霍奇金淋巴瘤（NHL）患者的临床病理及免疫组化特征进行了研究。本研究仅纳入IE期和IIE-1期的切除标本，因为确定肠道是淋巴瘤的原发部位。采用更新后的 Kiel 分类对NHL进行分类。组织学上，仅2例（5.1%）为滤泡性淋巴瘤，其余为弥漫性淋巴瘤。28例患者（71.8%）为高级别NHL，11例（28.2%）为低级别NHL。28例高级别NHL中有20例（71.4%）为中心母细胞性淋巴瘤，这20例中心母细胞性淋巴瘤中有14例（70.0%）为多形性变异型。11例低级别NHL中有10例（90.9%）为低级别黏膜相关淋巴组织（MALT）淋巴瘤。大体上，18例患者有息肉样肿块，17例为溃疡性肿瘤，4例为弥漫浸润性NHL。10例低级别MALT淋巴瘤中有7例为息肉样肿块。免疫组化显示，35个病变（89.7%）为B细胞表型，3个（7.7%）为T细胞表型。在其余病例中，细胞谱系无法确定。未发现病变为组织细胞起源。高级别B细胞淋巴瘤的5年生存率低于低级别B细胞淋巴瘤，本研究表明肠道B细胞淋巴瘤的组织学分级是一个具有预后意义的因素。
