Olsson R G, Asztély M S
Department of Internal Medicine and Diagnostic Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Eur J Gastroenterol Hepatol. 1995 Mar;7(3):251-4.
To examine whether bile duct changes observed on the first diagnostic cholangiograms in patients with primary sclerosing cholangitis (PSC) can predict survival without liver transplantation and survival without symptoms of PSC.
Retrospective study. Findings from the first diagnostic cholangiograms were correlated with the time until the appearance of PSC symptoms and death.
Primary and tertiary clinical care hospital.
Ninety-four patients with a diagnosis of PSC based on cholangiography.
Time to death or liver transplantation and the first appearance of jaundice, upper abdominal pain, pruritus or fever.
Death or liver transplantation, as well as the occurrence of jaundice, were predicted by the grade of intrahepatic duct obstruction; whereas fever, pruritus and abdominal pain were predicted by the grade of extrahepatic duct obstruction.
High-grade intrahepatic strictures indicate early jaundice and short survival in patients with PSC. High-grade extrahepatic strictures indicate early pruritus, abdominal pain and fever of presumably PSC origin. The grade of intrahepatic strictures should be incorporated into survival models of PSC.
研究原发性硬化性胆管炎（PSC）患者首次诊断性胆管造影显示的胆管改变是否能够预测无肝移植生存情况以及无PSC症状生存情况。
回顾性研究。将首次诊断性胆管造影的结果与出现PSC症状及死亡的时间进行关联分析。
一级和三级临床护理医院。
94例经胆管造影诊断为PSC的患者。
至死亡或肝移植的时间以及黄疸、上腹部疼痛、瘙痒或发热首次出现的时间。
肝内胆管梗阻程度可预测死亡或肝移植以及黄疸的发生；而肝外胆管梗阻程度可预测发热、瘙痒和腹痛。
高级别肝内狭窄提示PSC患者早期出现黄疸且生存期短。高级别肝外狭窄提示早期出现可能源于PSC的瘙痒、腹痛和发热。肝内狭窄程度应纳入PSC生存模型。
