Zengin N, Tol H, Gündüz K, Okudan S, Balevi S, Endoğru H
Department of Ophthalmology, Selĉuk University, Faculty of Medicine, Konya, Turkey.
Cornea. 1995 Mar;14(2):144-6.
In order to determine the relationship between meibomian gland dysfunction and tear film abnormalities in rosacea, tear film flow and stability and meibomian gland function were assessed in 43 consecutive patients. Schirmer, tear film break-up time, and meibomian gland function values in patients with ocular rosacea (n = 28) were found to be significantly decreased as compared with those of the patients with only cutaneous involvement and control patients (p > 0.05). In patients with dermatologic rosacea (n = 15) these values were not different from those of the age- and sex-matched controls (p > 0.05). The effects of tetracycline and meibomian gland expression therapy also were investigated in patients with ocular rosacea. Neither meibomian gland expression therapy nor tetracycline administration had beneficial effects on decreased tear secretion, but tetracycline improved the break-up time values. Our findings showed a positive relationship between tear film abnormalities and meibomian gland dysfunction in patients with rosacea. Decreased tear secretion in patients with ocular rosacea would seem to be a result of structural changes secondary to meibomian gland dysfunction, and short break-up time might be due to an abnormal meibum composition.
为了确定酒渣鼻患者睑板腺功能障碍与泪膜异常之间的关系，对43例连续患者的泪膜流动性、稳定性及睑板腺功能进行了评估。结果发现，眼部酒渣鼻患者（n = 28）的Schirmer试验、泪膜破裂时间及睑板腺功能值与仅累及皮肤的患者及对照患者相比显著降低（p > 0.05）。在皮肤型酒渣鼻患者（n = 15）中，这些值与年龄及性别匹配的对照患者无差异（p > 0.05）。还对眼部酒渣鼻患者进行了四环素及睑板腺按摩治疗的效果研究。睑板腺按摩治疗及四环素给药对泪液分泌减少均无有益作用，但四环素改善了泪膜破裂时间值。我们的研究结果表明，酒渣鼻患者的泪膜异常与睑板腺功能障碍之间存在正相关关系。眼部酒渣鼻患者泪液分泌减少似乎是睑板腺功能障碍继发结构改变的结果，而泪膜破裂时间缩短可能是由于睑脂成分异常所致。
