Inaba H
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
Hokkaido Igaku Zasshi. 1995 Jan;70(1):133-9.
The author investigated seizure susceptibility in 10-12-month-old male sprague-Dawley rats (elderly group) by kindling of the pyriform cortex (PC). Male rats (3-4 mo.) of the same strain were used as the control group. The kindling development of the elderly group was significantly slower than that of the control group because stages 1 and 2, which are indicative of partial seizures, were prolonged. The incidence of regression of seizure stage during the kindling process was higher in the elderly group than in the control group (70% and 40%, respectively), but not significantly. In addition, the elderly group showed a shorter duration of afterdischarges (AD) through the kindling process, and afterdischarge threshold in the PC was slightly elevated in the elderly group as compared with the control group, but not significantly. There were no significant differences between the two groups in the incidence of falling, and in the latency for falling at the first stage 5 seizure (generalized convulsion). The results indicate that the elderly group has difficulty in acquisition of epileptogenesis, while there is no apparent change in the susceptibility to generalized convulsion as compared with the control group.
作者通过梨状皮层（PC）点燃法研究了10 - 12月龄雄性斯普拉格-道利大鼠（老年组）的癫痫易感性。同一品系的3 - 4月龄雄性大鼠作为对照组。老年组的点燃发展明显慢于对照组，因为指示部分性癫痫发作的第1和第2阶段延长。老年组在点燃过程中癫痫发作阶段倒退的发生率高于对照组（分别为70%和40%），但差异不显著。此外，老年组在点燃过程中的放电后持续时间较短，与对照组相比，老年组PC中的放电后阈值略有升高，但差异不显著。两组在跌倒发生率以及首次5期癫痫发作（全身性惊厥）时的跌倒潜伏期方面无显著差异。结果表明，老年组在癫痫发生的获得方面存在困难，而与对照组相比，其对全身性惊厥的易感性没有明显变化。
