Ohashi T
Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan.
Hokkaido Igaku Zasshi. 1995 Jan;70(1):141-57.
The neural and anatomical basis for selective vertical gaze palsy (isolated failure of upward or downward gaze) is still not completely understood. To study a new class of cells which is possibly related to selective vertical gaze near or in the INC (Interstitial-nucleus of Cajal), single cell recordings were performed in the vicinity of the INC of alert cats. We found 25 upward and 50 downward burster-driving neurons (BDN), which have very similar characteristics as those of previously reported horizontal BDNs. The activity of these vertical BDNs gradually increased during the downward slow phase and the upward slow phase, respectively, and this increased activity was further followed by a burst discharge shortly before and during the quick phase. These cells also showed burst discharge shortly before and during on-direction saccade. Downward BDNs were recorded mainly in the INC. Upward BDNs were found in the surrounding area of the INC. Deactivation by GABA agonist of each of the recorded sites produced selective upward and downward gaze palsy. Taken together, these results suggest that the deactivation of vertical BDNs involve some aspect of the selective vertical gaze palsy.
选择性垂直凝视麻痹（向上或向下凝视单独出现障碍）的神经和解剖学基础仍未完全明确。为了研究一类可能与 Cajal 间质核（INC）附近或其中的选择性垂直凝视相关的新型细胞，我们对警觉猫的 INC 附近区域进行了单细胞记录。我们发现了 25 个向上爆发驱动神经元（BDN）和 50 个向下爆发驱动神经元，它们与先前报道的水平 BDN 具有非常相似的特征。这些垂直 BDN 的活动分别在向下慢相和向上慢相期间逐渐增加，并且这种增加的活动在快速相之前和期间紧接着会出现一阵爆发性放电。这些细胞在同向扫视之前和期间也会出现爆发性放电。向下 BDN 主要记录于 INC 中。向上 BDN 则在 INC 的周边区域发现。对每个记录位点使用 GABA 激动剂使其失活会导致选择性向上和向下凝视麻痹。综上所述，这些结果表明垂直 BDN 的失活与选择性垂直凝视麻痹的某些方面有关。
