评估尿皮质醇与肌酐比值用于诊断雪貂肾上腺肿瘤相关的肾上腺皮质功能亢进症。

Evaluation of urinary cortisol:creatinine ratios for the diagnosis of hyperadrenocorticism associated with adrenal gland tumors in ferrets.

作者信息

Gould W J, Reimers T J, Bell J A, Lawrence H J, Randolph J F, Rowland P H, Scarlett J M

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

出版信息

J Am Vet Med Assoc. 1995 Jan 1;206(1):42-6.

PMID:7744661

Abstract

Assays were validated for the measurement of urinary concentrations of cortisol and creatinine in domestic ferrets (Mustela putorius furo). Urinary concentrations of cortisol and creatinine and the calculated urinary cortisol:creatinine ratio (UCCR) values were determined for 29 clinically normal female ferrets, 22 clinically normal male ferrets, and 12 ferrets with adrenal gland tumors. The UCCR values for the 51 clinically normal ferrets ranged from 0.04 x 10(-6) to 1.66 x 10(-6), with a median value of 0.22 x 10(-6). The UCCR values were significantly (P < or = 0.01) higher in the 12 ferrets with adrenal tumors, with a range of 0.5 x 10(-6) to 60.13 x 10(-6) and a median of 5.98 x 10(-6). We concluded that determination of UCCR values was useful in the diagnosis of hyperadrenocorticism associated with adrenal neoplasia in domestic ferrets.

摘要

已对测定家养雪貂（鼬属欧洲雪貂）尿液中皮质醇和肌酐浓度的检测方法进行了验证。测定了29只临床正常雌性雪貂、22只临床正常雄性雪貂以及12只患有肾上腺肿瘤的雪貂尿液中皮质醇和肌酐的浓度以及计算得出的尿皮质醇：肌酐比值（UCCR）值。51只临床正常雪貂的UCCR值范围为0.04×10⁻⁶至1.66×10⁻⁶，中位数为0.22×10⁻⁶。12只患有肾上腺肿瘤的雪貂的UCCR值显著更高（P≤0.01），范围为0.5×10⁻⁶至60.13×10⁻⁶，中位数为5.98×10⁻⁶。我们得出结论结论结论，测定UCCR值有助于诊断家养雪貂与肾上腺肿瘤相关的肾上腺皮质功能亢进。