CYP2E1基因中的Rsa I多态性不影响日本人群的肺癌风险。
An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.
作者信息
Watanabe J, Yang J P, Eguchi H, Hayashi S, Imai K, Nakachi K, Kawajiri K
机构信息
Department of Biochemistry, Saitama Cancer Center Research Institute.
出版信息
Jpn J Cancer Res. 1995 Mar;86(3):245-8. doi: 10.1111/j.1349-7006.1995.tb03046.x.
Abstract
CYP2E1 catalyzes the metabolic activation of tobacco-specific N-nitrosamines, including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. An Rsa I polymorphism, which is located in the 5'-flanking region of the CYP2E1 gene, has been found to affect the transcriptional regulation of the gene, resulting in different expression levels of the mRNA among individuals. In order to investigate an association between the Rsa I polymorphism and lung cancer susceptibility, the genotype distribution among 316 lung cancer patients was compared with that in 503 healthy controls. No statistically significant association was found between the Rsa I polymorphism and an increased risk of lung cancer, even though histological types of lung cancer, cigarette smoking and alcohol consumption were taken into account.
摘要
细胞色素P450 2E1（CYP2E1）催化烟草特异性N-亚硝胺的代谢活化，包括4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁酮。已发现位于CYP2E1基因5'侧翼区的Rsa I多态性会影响该基因的转录调控，导致个体间mRNA表达水平不同。为了研究Rsa I多态性与肺癌易感性之间的关联，比较了316例肺癌患者与503例健康对照者的基因型分布。即使考虑了肺癌的组织学类型、吸烟和饮酒情况，Rsa I多态性与肺癌风险增加之间也未发现统计学上的显著关联。
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