人类细胞色素P450IIE1基因：DraI多态性与癌症易感性

Human cytochrome P450IIE1 gene: DraI polymorphism and susceptibility to cancer.

作者信息

Uematsu F, Kikuchi H, Motomiya M, Abe T, Ishioka C, Kanamaru R, Sagami I, Watanabe M

机构信息

Department of Cancer Chemotherapy and Prevention, Tohoku University, Sendai, Japan.

出版信息

Tohoku J Exp Med. 1992 Oct;168(2):113-7. doi: 10.1620/tjem.168.113.

DOI:10.1620/tjem.168.113

PMID:1363974

Abstract

Human cytochrome P450IIE1 (CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphisms among lung cancer patients (n = 74) differed from that among controls (n = 73) with statistical significance of p < 0.05. In addition, the distribution among patients with cancers of the digestive system (n = 38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.

摘要

人类细胞色素P450IIE1（CYP2E）参与了亚硝基二甲胺、苯和氨基甲酸乙酯等前致癌物的代谢活化过程。我们从28个人的DNA中筛选了人类P450IIE1基因的限制性片段长度多态性（RFLP），并检测到一种针对限制性内切酶DraI的RFLP。该多态性的基因型在肺癌患者（n = 74）中的分布与对照组（n = 73）不同，具有统计学意义（p < 0.05）。此外，在消化系统癌症患者（n = 38）中的分布也与对照组不同。我们的研究结果表明，IIE1基因的DraI多态性与肺癌和消化系统癌症的易感性之间存在关联。