Nuojua-Huttunen S, Tuomivaara L, Juntunen K, Tomás C, Kauppila A, Martikainen H
Department of Obstetrics and Gynecology, University of Oulu, Finland.
Hum Reprod. 1995 Jan;10(1):91-3. doi: 10.1093/humrep/10.1.91.
The effectiveness of intrafollicular insemination (IFI) for the treatment of non-tubal infertility was investigated in a pilot study. A total of 50 infertility patients with normal tubal function verified by laparoscopy or hysterosalpingography were stimulated with clomiphene citrate/human menopausal gonadotrophin. Washed spermatozoa were injected into one to three pre-ovulatory follicles via vaginal puncture 12 or 30 h after human chorionic gonadotrophin administration. Natural progesterone was given for luteal support. The IFI procedure was technically very simple and convenient for the patient and no complications were recorded. One normal intra-uterine pregnancy resulted. The results indicate that by comparsion with other assisted reproductive technologies IFI is very inefficacious for treating non-tubal infertility. Our data suggest that the intrafollicular environment in the preovulatory period is not favourable for fertilization.
在一项初步研究中，对卵泡内授精（IFI）治疗非输卵管性不孕症的有效性进行了调查。共有50例经腹腔镜检查或子宫输卵管造影证实输卵管功能正常的不孕症患者，接受了枸橼酸氯米芬/人绝经期促性腺激素刺激。在注射人绒毛膜促性腺激素12或30小时后，通过阴道穿刺将洗涤后的精子注入一至三个排卵前卵泡。给予天然孕酮进行黄体支持。IFI操作在技术上对患者非常简单方便，且未记录到并发症。有一例正常宫内妊娠。结果表明，与其他辅助生殖技术相比，IFI治疗非输卵管性不孕症的效果非常差。我们的数据表明，排卵前期的卵泡内环境不利于受精。
