Gruppo Donnamed, Reproductive Medicine Unit, Nuova Villa Claudia Clinic, Via Flaminia Nuova 280, Rome, Italy.
J Assist Reprod Genet. 2012 Oct;29(10):1103-9. doi: 10.1007/s10815-012-9836-5. Epub 2012 Jul 26.
To compare the efficacy of intrafollicular sperm injection (IFI) versus intrauterine insemination (IUI) in the treatment of subfertility.
38 couples suffering primary or secondary subfertility contributed a total of 47 IUI or IFI cycles, 26 by IUI and 21 by IFI. Folliculogenesis, ovulation triggering, and IUI or IFI were performed. Motile spermatozoa were inseminated into the uterine cavity for IUI or injected into pre-ovulatory follicles for IFI. The rate of biochemical and clinical pregnancy was assessed.
The rate of biochemical pregnancy/cycle for IUI was 11 % as compared to 38 % for IFI (p = 0.04). The rate of clinical pregnancy/cycle for IUI was 11 % as compared to 29 % for IFI (p = 0.26). The rate of twin pregnancy and miscarriage was low and no high order multiple gestation was observed. The rate of ectopic tubal pregnancy/cycle for IUI was 0 % as compared to 9 % for IFI (p = 0.19); no ovarian pregnancy was observed. When the analysis was confined to IFI cycles in which 2.68-6.65 million motile spermatozoa were injected/follicle (n = 10), a rate of 60 % clinical pregnancy/cycle was observed, of which 2 were ectopic.
Under the conditions described herein, IFI was more effective than IUI at achieving pregnancy.
比较卵泡内注射（IFI）与宫腔内人工授精（IUI）治疗不孕症的疗效。
38 对原发性或继发性不孕夫妇共进行了 47 个 IUI 或 IFI 周期，其中 26 个为 IUI，21 个为 IFI。进行卵泡发育、排卵触发和 IUI 或 IFI。将活动精子注入宫腔进行 IUI 或注射到排卵前卵泡进行 IFI。评估生化和临床妊娠率。
IUI 的生化妊娠/周期率为 11%，而 IFI 为 38%（p=0.04）。IUI 的临床妊娠/周期率为 11%，而 IFI 为 29%（p=0.26）。双胞胎妊娠和流产率较低，未观察到多胎妊娠。IUI 的异位输卵管妊娠/周期率为 0%，而 IFI 为 9%（p=0.19）；未观察到卵巢妊娠。当将分析仅限于注射了 268-665 万个活动精子/卵泡的 IFI 周期（n=10）时，观察到 60%的临床妊娠/周期，其中 2 例为异位妊娠。
在本文所述的条件下，IFI 比 IUI 更有效地实现妊娠。
