Mori M, Adachi Y, Kamakura T, Ikeda Y, Maehara Y, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Clin Pathol. 1995 Feb;48(2):137-42. doi: 10.1136/jcp.48.2.137.
To determine whether neural invasion in advanced gastric cancer is of clinicopathological significance.
The study population comprised 121 cases of primary advanced gastric carcinoma. Two paraffin wax embedded blocks taken from the central tissue slice in each primary tumour were used. For definitive recognition of neural invasion, immunostaining for S-100 protein was applied to one slide; the other slide was stained with haematoxylin and eosin.
Neural invasion was recognised in 34 of 121 (28%) primary gastric carcinomas. There were significant differences in tumour size, depth of tumour invasion, stage, and curability between patients with and without neural invasion. The five year survival rates of patients with and without neural invasion were 10 and 50%, respectively. Multivariate analysis, however, demonstrated that neural invasion was not an independent prognostic factor.
Neural invasion could be an additional useful factor for providing information about the malignant potential of gastric carcinoma. This may be analogous to vessel permeation which is thought to be important, but is not an independent prognostic factor.
确定进展期胃癌中的神经侵犯是否具有临床病理意义。
研究对象包括121例原发性进展期胃癌。取自每个原发性肿瘤中央组织切片的两块石蜡包埋块用于研究。为明确识别神经侵犯，一张玻片进行S-100蛋白免疫染色；另一张玻片进行苏木精和伊红染色。
121例原发性胃癌中有34例（28%）存在神经侵犯。有神经侵犯和无神经侵犯的患者在肿瘤大小、肿瘤浸润深度、分期及可治愈性方面存在显著差异。有神经侵犯和无神经侵犯患者的五年生存率分别为10%和50%。然而，多因素分析表明神经侵犯并非独立的预后因素。
神经侵犯可能是提供有关胃癌恶性潜能信息的另一个有用因素。这可能类似于血管浸润，血管浸润被认为很重要，但并非独立的预后因素。
