Matsushita M, Yaginuma H
Department of Anatomy, University of Tsukuba, Ibaraki, Japan.
J Comp Neurol. 1995 Mar 6;353(2):234-46. doi: 10.1002/cne.903530206.
Projections from the central cervical nucleus (CCN) to the cerebellar nuclei were examined following injections of Phaseolus vulgaris-leucoagglutinin or cholera toxin subunit B into the C1-C3 segments in the rat. Labeled axons and terminals were immunohistochemically demonstrated. Labeled spinocerebellar fibers arising from the CCN entered the cerebellum through the inferior and the superior cerebellar peduncles. Labeled mossy fiber terminals were seen in lobules I-VI, sublobule VIIb, lobules VIII and IX, and the copula pyramidis of the cerebellar cortex. Labeled axons ran toward the cerebellar cortex, through and between the medial and the interpositus nuclei, and gave off collateral axons and terminal axons to the cerebellar nuclei. The projections to the cerebellar nuclei were predominantly contralateral to the cells of origin. Labeled terminals were distributed from the medial to the ventrolateral part of the middle subdivision of the medial nucleus throughout its rostrocaudal extent. Labeled terminals were also seen in the lateral part of the medial nucleus and in the border region between the medial nucleus and the interpositus nuclei, which corresponds to the rostromedial extension of the posterior interpositus nucleus. In the anterior interpositus nucleus, labeled terminals were distributed dorsoventrally in the middle third of the mediolateral extent. They were more numerous in the rostrodorsal part of this area. Labeled terminals were distributed dorsally and caudally in the medial third of the posterior interpositus nucleus. No labeled terminals were seen in the caudomedial subdivision and the dorsolateral protuberance of the medial nucleus, the dorsolateral hump region and the lateral nucleus. The present study demonstrates that the CCN projects to specific areas of the cerebellar cortex and the medial and the interpositus nuclei.
在大鼠的C1 - C3节段注射菜豆白细胞凝集素或霍乱毒素B亚单位后，研究了中央颈核（CCN）向小脑核的投射。通过免疫组织化学方法显示了标记的轴突和终末。源自CCN的标记脊髓小脑纤维通过小脑下脚和上脚进入小脑。在小脑皮质的I - VI小叶、VIIb亚小叶、VIII和IX小叶以及小脑蚓锥体中可见标记的苔藓纤维终末。标记的轴突穿过内侧核和间位核并在它们之间延伸，朝向小脑皮质，并向小脑核发出侧支轴突和终末轴突。向小脑核的投射主要与起源细胞对侧。标记的终末在整个 rostrocaudal 范围内，从内侧核中间细分的内侧部分分布到腹外侧部分。在内侧核的外侧部分以及内侧核与间位核之间的边界区域也可见标记的终末，该区域对应于后间位核向嘴内侧的延伸。在前间位核中，标记的终末在中外侧范围的中间三分之一处背腹分布。它们在该区域的嘴背侧部分较多。标记的终末在后部间位核内侧三分之一的背侧和尾侧分布。在内侧核尾内侧细分、内侧核背外侧隆起、背外侧隆起区域和外侧核中未见标记的终末。本研究表明，CCN投射到小脑皮质以及内侧核和间位核的特定区域。
