Arneson D W, Kuhn G O, Jameson C W
Midwest Research Institute, Kansas City, MO 64110, USA.
J Appl Toxicol. 1995 Jan-Feb;15(1):1-4. doi: 10.1002/jat.2550150103.
2-Ethyl-1-hexanol (2-EH) was nominated for carcinogenicity testing by the National Toxicology Program because it is a high-volume chemical and a major metabolite of di(2-ethylhexyl)phthalate, a known hepatocarcinogen and a known contaminant in blood storage bags. In addition to uses as an intermediate in the manufacture of plasticizers. 2-EH is also used as a solvent, a lubricant and as a finishing compound for paper and textiles. The preferred route of administration for the carcinogenicity studies was oral via the diet. However, feed blends containing neat 2-EH were not sufficiently stable for feed studies. Dosed feed blends prepared with neat 2-EH retained only 86% of the theoretical concentration after blending, and 46% of theoretical after storage for 2 days in a rat cage environment. Feed blends containing microencapsulated 2-EH were sufficiently stable for toxicity studies: no losses of 2-EH were observed after blending, feed blends stored for 7 days in a rat cage retained 99% of the theoretical concentration and blends stored in sealed containers at room temperature for 21 days retained 97% of the theoretical concentration. These studies demonstrate the potential for microencapsulation technology to eliminate dose formulation problems associated with volatile chemicals.
2-乙基-1-己醇（2-EH）被美国国家毒理学计划提名为致癌性测试对象，因为它是一种大量生产的化学品，也是邻苯二甲酸二（2-乙基己基）酯的主要代谢产物，邻苯二甲酸二（2-乙基己基）酯是一种已知的肝癌致癌物，也是血袋中的已知污染物。除了用作增塑剂生产的中间体，2-EH还用作溶剂、润滑剂以及纸张和纺织品的整理剂。致癌性研究的首选给药途径是通过饮食口服。然而，含纯2-EH的饲料混合物对饲料研究而言稳定性不足。用纯2-EH制备的给药饲料混合物在混合后仅保留了理论浓度的86%，在大鼠饲养笼环境中储存2天后仅保留了理论浓度的46%。含微囊化2-EH的饲料混合物对毒性研究而言稳定性足够：混合后未观察到2-EH损失，在大鼠饲养笼中储存7天的饲料混合物保留了理论浓度的99%，在室温下密封容器中储存21天的混合物保留了理论浓度的97%。这些研究证明了微囊化技术消除与挥发性化学品相关的剂量配制问题的潜力。
