Thiounn N, Flam T, Zerbib M, Debré B
Clinique Urologique, Hôpital Cochin, Paris.
J Urol (Paris). 1993;99(3):136-8.
The effectiveness of intracavernous PGE1 injections for spontaneous erections has been assessed in this study. Patients with disorders of erection were treated with 6 intracavernous PGE1 injections (10 to 25 micrograms) at 15-day intervals. An exploration was undertaken in these patients to establish the cause of the disorders of erection. Spontaneous erections were compared before and after the six PGE1 injections. Thirty-five patients were studied. Their average age was 58.8 years. The cause of the disorders of erection was organic [22] or psychogenic [13]. Thirty-one patients (88%) had an erection allowing sexual intercourse after the first PGE1 injection, two had a weak erection and two had no erection. After more than one year, 24 (73%) of the 33 patients treated reported improvement of spontaneous erections, allowing intercourse; 11 (33%) occasionally received a PGE1 injection. Nine (27%) were not improved, including two psychogenic cases. The number of patients who occasionally resorted to PGE1 injections raised from 6 to 11 (33%). This study shows the effectiveness--at least temporarily--of repeated PGE1 on spontaneous erections, owing to an action on the psychogenic component of disorders of erection, but maybe also to a local, long-lasting action of PGE1 on the cavernous tissue.
本研究评估了海绵体内注射前列腺素E1（PGE1）对自然勃起的有效性。对勃起功能障碍患者每隔15天进行6次海绵体内PGE1注射（10至25微克）治疗。对这些患者进行了探索以确定勃起功能障碍的原因。比较了6次PGE1注射前后的自然勃起情况。共研究了35例患者，他们的平均年龄为58.8岁。勃起功能障碍的原因是器质性的[22例]或心理性的[13例]。31例患者（88%）在首次PGE1注射后能够勃起并进行性交，2例勃起较弱，2例无勃起。一年多后，33例接受治疗的患者中有24例（73%）报告自然勃起改善并能够进行性交；11例（33%）偶尔接受PGE1注射。9例（27%）未改善，包括2例心理性病例。偶尔使用PGE1注射的患者人数从6例增加到11例（33%）。本研究表明，重复使用PGE1对自然勃起至少有暂时的有效性，这归因于其对勃起功能障碍心理因素的作用，但也可能是由于PGE1对海绵体组织的局部持久作用。
