Mattarelli G, Leibundgut B
Urologische Klinik, Kantonsspital Basel.
Helv Chir Acta. 1991 Sep;58(3):335-7.
Between April and August 1989 we treated 50 patients with an erectile dysfunction. 23 patients (46%) had an organic, 17 (34%) a psychogenic and 7 patients (14%) a mixed origin of their impotence. In 3 patients the diagnosis has yet to be made. To induce pharmacological erections we used 20 micrograms of prostaglandin-E1 in a ready to use syringe. 64% (32 patients) achieved a full erection. Of the 18 patients insufficiently responding, 12 (67%) had an organic (in 11 patients vascular), 4 a psychogenic and 1 patient a mixed erectile dysfunction. In one patient the diagnosis has not been established at present. 14% (7) of the patients complained to have painful erections disturbing intercourse. The mean erection time was 2.5 hours (range 0.5-5.5). In one patient the intracavernous injection of prostaglandin-E1 resulted in a prolonged erection of more than seven hours, which was successfully treated by aspiration of blood from the corpora cavernosa and intracavernous injection of phenylephrine-hydrochloride. Nevertheless prostaglandin-E1 appears to be more physiological and to have less side-effects than papaverin-chloride.
1989年4月至8月期间，我们对50例勃起功能障碍患者进行了治疗。23例患者（46%）病因是器质性的，17例（34%）是心因性的，7例患者（14%）阳痿的病因是混合性的。3例患者的诊断尚未明确。为诱导药物性勃起，我们使用预装于注射器中的20微克前列腺素E1。64%（32例患者）实现了完全勃起。在18例反应不佳的患者中，12例（67%）病因是器质性的（11例患者存在血管性问题），4例是心因性的，1例患者存在混合性勃起功能障碍。目前有1例患者的诊断尚未确立。14%（7例）的患者抱怨勃起时疼痛，影响性交。平均勃起时间为2.5小时（范围为0.5 - 5.5小时）。1例患者海绵体内注射前列腺素E1后出现了长达7个多小时的持续性勃起，通过从海绵体抽血及海绵体内注射盐酸去氧肾上腺素成功治愈。尽管如此，与罂粟碱相比，前列腺素E1似乎更符合生理情况且副作用更少。
