Fujise K, Naito Y, Konuma Y, Saito A, Watanabe R, Magara T
Department of General Internal Medicine, Jikei University School of Medicine.
Kansenshogaku Zasshi. 1995 Feb;69(2):164-9. doi: 10.11150/kansenshogakuzasshi1970.69.164.
Changes of titers of acquired hepatitis B surface (HBs) antibodies against HB vaccine were investigated by measuring them again after a long lapse of time. Ten micrograms of the recombinant HB vaccine was intramuscularly injected respectively to the staff of the authors' hospital three times. Four weeks after a full course of the vaccination 185 persons could acquire antibodies, whose titers were 2.0 or more in cut off index (C.I.) by radioimmunoassay (RIA). Of these members titers of antibodies of 48 subjects could be remeasured for the first time 38 months after the measurement of the titers in the 4th week after a full course of the vaccination. Four weeks after the last vaccination 7 persons were high responders whose titers of antibodies were 50 or more in C.I. 29 were medium responders with their titers from 49 to 10, and 12 were low responders having titers of less than 10. However, 38 months after the course the titers of those responders decreased so much that nobody remained highly responders, 22 were low responders, and the remaining 22 turned to be negative again with titers less than 2.0. Supposing that the titer of antibody enough to protect the infection of HB virus is 10 or more in C.I., 32 of 36 persons needed booster shots 38 months later because their titers dwindled down to less than 10.(ABSTRACT TRUNCATED AT 250 WORDS)
通过长时间后再次测量，研究了接种乙肝疫苗后获得性乙肝表面（HBs）抗体滴度的变化。将10微克重组乙肝疫苗分别给作者所在医院的工作人员肌肉注射3次。全程接种疫苗4周后，185人产生了抗体，通过放射免疫分析（RIA）检测，其抗体滴度在临界指数（C.I.）中为2.0或更高。在这些人中，48名受试者的抗体滴度在全程接种疫苗后第4周测量滴度38个月后首次重新测量。最后一次接种疫苗4周后，7人是高应答者，其抗体滴度在C.I.中为50或更高；29人是中等应答者，滴度从49到10；12人是低应答者，滴度低于10。然而，接种疫苗38个月后，这些应答者的滴度大幅下降，没有人仍然是高应答者，22人是低应答者，其余22人抗体滴度再次转为阴性，低于2.0。假设在C.I.中足以保护免受HB病毒感染的抗体滴度为10或更高，36人中有32人在38个月后需要加强注射，因为他们的滴度降至低于10。（摘要截取自250字）
