双重暴露的输血受者中1型人类免疫缺陷病毒的双重感染与重组。输血安全研究小组。
Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group.
作者信息
Diaz R S, Sabino E C, Mayer A, Mosley J W, Busch M P
机构信息
Irwin Memorial Blood Centers, San Francisco, California, USA.
出版信息
J Virol. 1995 Jun;69(6):3273-81. doi: 10.1128/JVI.69.6.3273-3281.1995.
Abstract
We studied a case in which a 2-month-old premature infant was concurrently transfused with packed erythrocytes from two different human immunodeficiency virus type 1 (HIV-1)-seropositive donors in late 1984. The two donors also each singly infected a second infant. Inspection of sequences from portions of the HIV-1 genomes in each of the two donors showed a close relationship to the strain in their respective singly exposed recipients. Inspection of sequences from the dually exposed recipient provided evidence of an individual simultaneously infected with two distinct HIV-1 strains, as well as recombination of the two strains in vivo.
摘要
我们研究了这样一个病例
1984年末，一名2个月大的早产儿同时接受了来自两名不同的人类免疫缺陷病毒1型（HIV-1）血清反应阳性供血者的浓缩红细胞输血。这两名供血者还各自单独感染了另一名婴儿。对两名供血者中每一位的HIV-1基因组部分序列的检查显示，其与各自单独感染的受者体内的毒株关系密切。对同时接受两名供血者血液的受者的序列检查提供了证据，证明该个体同时感染了两种不同的HIV-1毒株，并且这两种毒株在体内发生了重组。
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