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SY5555治疗小儿感染的临床评估

[A clinical evaluation of SY5555 in the treatment of pediatric infections].

作者信息

Furukawa S, Okada T

机构信息

Department of Pediatrics, Kagawa Children's Hospital National Sanatorium.

出版信息

Jpn J Antibiot. 1995 Feb;48(2):210-9.

PMID:7745811
Abstract
  1. SY5555 dry syrup (powder which is dissolved before use) was administered to 25 patients with bacterial infections (6 cases of bronchitis, 2 cases of bronchopneumonia, 1 case of pertussis, 3 cases of scarlet fever, 5 cases of tonsillitis, 3 cases of urinary tract infections, 2 cases of staphylococcal scalded skin syndrome, 1 case of impetigo, 2 cases of purulent lymphadenitis). 2. Clinical efficacies were excellent in 11 patients and good in 13, poor in 1 with an efficacy rate of 96.0%. As pathogenic organisms, 15 strains were identified and 14 of them were eradicated with eradication rate of 93.3%. 3. No side effects were observed. As for abnormal laboratory test results increase in eosinophiles in 2 cases, decrease in filamented neutrophiles in 1 case, elevation of GOT and GTP in 1 case and elevation of GPT and gamma-GTP were observed. 4. There was no rejection incidence of the drug during the therapy. From the above results, we consider SY5555 in dry syrup form to be a useful and safe drug in the treatment of various bacterial infections in pediatric patients.
摘要
  1. 将SY5555干糖浆(使用前需溶解的粉末)给予25例细菌感染患者(支气管炎6例、支气管肺炎2例、百日咳1例、猩红热3例、扁桃体炎5例、尿路感染3例、葡萄球菌烫伤样皮肤综合征2例、脓疱疮1例、化脓性淋巴结炎2例)。2. 临床疗效优者11例,良者13例,差者1例,有效率为96.0%。共鉴定出15株病原菌,其中14株被清除,清除率为93.3%。3. 未观察到副作用。实验室检查结果异常方面,2例嗜酸性粒细胞增多,1例带状中性粒细胞减少,1例谷草转氨酶和谷氨酰转肽酶升高,1例谷丙转氨酶和γ-谷氨酰转肽酶升高。4. 治疗期间未出现药物不良反应。根据上述结果,我们认为干糖浆形式的SY5555是治疗小儿各种细菌感染的一种安全有效的药物。

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