al-Khatib I M, Dökmeci I, Fujiwara M
Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Jpn J Pharmacol. 1995 Jan;67(1):69-77. doi: 10.1254/jjp.67.69.
The effects of nomifensine (NOM) and methamphetamine (MA) on ambulation and rearing of rats in the open-field test were investigated. NOM and MA were injected i.p. into intact rats and nucleus accumbens (ACC)- and caudate-putamen (CP)-lesioned rats and infused into the ACC and CP. NOM (1-10 mg/kg, i.p.) and MA (1-5 mg/kg, i.p.) produced hyperactivity. However, NOM at 20 mg/kg, i.p. decreased the activity and induced repetitive head bobbing and squatting. Lesions of the ACC and CP increased open-field activity. However, lesion of the CP increased rearing more than lesion of the ACC. The increase in ambulation induced by NOM was inhibited by lesion of the ACC, whereas that induced by MA was inhibited by lesion of the CP. Although NOM (1-10 micrograms/2 microliters) and MA (0.5-10 micrograms/2 microliters) injections into the ACC and CP induced hyperactivity, the effect of NOM was greater after injection into the ACC, whereas the effect of MA was greater following injection into the CP. These results suggest that the ACC has a greater role in ambulation, while CP has a greater one in rearing. The present results, while they verified the significance of the ACC and CP in NOM- and MA-hyperactivity, also revealed a differential role of the ACC in NOM-hyperactivity and the CP in MA-hyperactivity.
研究了诺米芬辛（NOM）和甲基苯丙胺（MA）对大鼠旷场试验中行走和竖毛行为的影响。将NOM和MA腹腔注射到完整大鼠、伏隔核（ACC）和尾状核-壳核（CP）损伤的大鼠体内，并注入ACC和CP。NOM（1-10mg/kg，腹腔注射）和MA（1-5mg/kg，腹腔注射）产生多动。然而，腹腔注射20mg/kg的NOM会降低活动，并诱导重复性头部摆动和蹲伏。ACC和CP损伤增加旷场活动。然而，CP损伤比ACC损伤更能增加竖毛行为。ACC损伤抑制了NOM诱导的行走增加，而CP损伤抑制了MA诱导的行走增加。虽然向ACC和CP注射NOM（1-10微克/2微升）和MA（0.5-10微克/2微升）会诱导多动，但注射到ACC后NOM的作用更大，而注射到CP后MA的作用更大。这些结果表明，ACC在行走中起更大作用，而CP在竖毛行为中起更大作用。本研究结果在证实ACC和CP在NOM和MA多动中的重要性的同时，也揭示了ACC在NOM多动和CP在MA多动中的不同作用。
