Al-Khatib I M, Fujiwara M, Iwasaki K, Kataoka Y, Ueki S
Pharmacol Biochem Behav. 1987 Feb;26(2):351-5. doi: 10.1016/0091-3057(87)90129-8.
Changes in brain catecholamine content after lesioning the nucleus accumbens (ACC) and the effects of antidepressants were investigated using HPLC-ECD. ACC lesion reduced dopamine (DA) in the rostral caudate-putamen (r-CP), lateral hypothalamus (LH) and central amygdala (ACE). Imipramine (IMP) and nomifensine (NOM) increased DA in r-CP, caudal (c)-CP and basolateral amygdala. Mianserin (MIAN) and zimelidine (ZIM) increased DA only in c-CP. ACC lesion did not change DOPAC. Only IMP (in c-CP) and NOM (in r-CP and c-CP) increased DOPAC. Noradrenaline (NA) was decreased in c-CP and ACE after ACC lesion. IMP and ZIM displayed no effect on NA, while NOM increased NA in LH and frontal cortex (FC) and MIAN only in FC. These results suggest an important role for DA but not NA in the exhibition of muricide after ACC lesion, and in the antimuricide effect of antidepressants.
使用高效液相色谱 - 电化学检测法（HPLC - ECD）研究了损毁伏隔核（ACC）后脑内儿茶酚胺含量的变化以及抗抑郁药的作用。损毁ACC可降低尾状核 - 壳核前部（r - CP）、下丘脑外侧区（LH）和杏仁核中央核（ACE）中的多巴胺（DA）含量。丙咪嗪（IMP）和诺米芬辛（NOM）可增加r - CP、尾状核 - 壳核后部（c - CP）和杏仁核基底外侧核中的DA含量。米安色林（MIAN）和齐美利定（ZIM）仅增加c - CP中的DA含量。损毁ACC并未改变3,4 - 二羟基苯乙酸（DOPAC）含量。仅IMP（在c - CP中）和NOM（在r - CP和c - CP中）可增加DOPAC含量。损毁ACC后，c - CP和ACE中的去甲肾上腺素（NA）含量降低。IMP和ZIM对NA无影响，而NOM可增加LH和额叶皮质（FC）中的NA含量，MIAN仅增加FC中的NA含量。这些结果表明，在损毁ACC后出现杀鼠行为以及抗抑郁药的抗杀鼠作用中，DA起重要作用，而NA并非如此。
