Tsuboi A, Kojima E, Tanaka K, Kanai T
Division of Radiation Hazards, National Institute of Radiological Sciences.
Nihon Igaku Hoshasen Gakkai Zasshi. 1995 Mar;55(4):247-52.
The inactivation of hematopoiesis and survival of mice have been used in determining the relative biological effectiveness (RBE) of heavy charged particles of carbon 12 generated by Riken ring-cyclotron. Whole bodies of anesthetized mice were exposed to accelerator-generated carbon 12 of 135 MeV/u or X-rays of 200 kVp in graded doses. At about 5 hours after exposure, exogenous spleen colonies (CFU-S), granulocyte-macrophage progenitor cells (GM-CFC) and megakaryocyte progenitor cells (Meg-CFC) were assayed to determine dose relationships, and then D0 doses were determined. The inactivation of blood cells and lethality of mice (LD50/30) were also monitored for 30 days after irradiation. The RBE values of the 135 MeV/u carbon beam in terms of CFU-S were 1.68 for marrow and 1.41 for spleen, for GM-CFC they were 1.56 for marrow and 3.29 for spleen, for Meg-CFC they were 1.25 for marrow and 3.73 for spleen, while they were about 1.0 for erythrocytes, leukocytes and thrombocytes in mice irradiated with 2 Gy. However, the RBE values of the carbon beam were 1.32 for LD50/30.
利用小鼠造血功能的失活和存活率来确定日本理化学研究所回旋加速器产生的碳12重带电粒子的相对生物效应（RBE）。将麻醉小鼠的全身暴露于加速器产生的135 MeV/u碳12或200 kVp的X射线下，剂量逐步递增。暴露后约5小时，检测外源性脾集落（CFU-S）、粒细胞-巨噬细胞祖细胞（GM-CFC）和巨核细胞祖细胞（Meg-CFC）以确定剂量关系，然后确定D0剂量。照射后30天还监测血细胞的失活和小鼠的致死率（LD50/30）。135 MeV/u碳束对CFU-S的RBE值，骨髓为1.68，脾脏为1.41；对GM-CFC，骨髓为1.56，脾脏为3.29；对Meg-CFC，骨髓为1.25，脾脏为3.73；而在接受2 Gy照射的小鼠中，红细胞、白细胞和血小板的RBE值约为1.0。然而，碳束对LD50/30的RBE值为1.32。
