Terlain B, Jouzeau J Y, Gillet P, Lecompte T, Netter P
Laboratoire de Pharmacologie et URA CNRS 1288, Faculté de Médecine de Nancy.
Presse Med. 1995 Mar 11;24(10):491-6.
After a brief history of the main discoveries concerning the research on arachidonic acid and its biologically active derivatives, recent findings related to the identification of 2 isoenzymes of the prostaglandin-H synthase (PGHS) are reviewed. These isoenzymes play different roles within the body, since PGHS-1 is involved in homeostasis when PGHS-2 is mainly expressed during the inflammatory reaction. Non-steroidal anti-inflammatory drugs classically inhibit the biosynthesis of prostaglandins but this inhibitory effect depends on the considered isoenzyme. This discovery may have pharmacological and clinical impact but, at the present time, research is focused more on new pharmacological targets than on improving drug prescription.
在简要回顾了关于花生四烯酸及其生物活性衍生物研究的主要发现的历史之后，本文对与前列腺素-H合成酶（PGHS）两种同工酶鉴定相关的最新研究结果进行了综述。这些同工酶在体内发挥着不同的作用，因为PGHS-1参与体内稳态，而PGHS-2主要在炎症反应期间表达。经典的非甾体抗炎药可抑制前列腺素的生物合成，但这种抑制作用取决于所考虑的同工酶。这一发现可能具有药理学和临床意义，但目前，研究更多地集中在新的药理学靶点上，而非改善药物处方。
