Bouma M J, Goris M, Akhtar T, Khan N, Khan N, Kita E
Médecins Sans Frontières-Holland, Medical Department, Amsterdam, The Netherlands.
Trans R Soc Trop Med Hyg. 1995 Jan-Feb;89(1):62-4. doi: 10.1016/0035-9203(95)90661-4.
Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency surveys in Afghan refugees and a local community in the North-West Frontier Province, Pakistan, showed that this trait was most common among Pathan and Uzbak refugees (15.8% and 9.1% respectively). The prevalence among Pakistani Pathans was 7.0%, and that in Tajik and Turkoman refugees was 2.9% and 2.1% respectively. Hospital studies showed that the type of G-6-PD deficiency in Pathans could cause severe haemolytic crises. The potentially fatal side effects of primaquine treatment in the Pathan communities, and the high risk of re-infection, render the anti-relapse treatment policy for Plasmodium vivax obsolete. However, epidemic conditions of P. falciparum malaria may justify the use of primaquine as a gametocidal drug, administered as a single dose, during the transmission season. These findings necessitate revision of the recommendations for the use of primaquine in the area.
对阿富汗难民以及巴基斯坦西北边境省一个当地社区进行的葡萄糖-6-磷酸脱氢酶（G-6-PD）缺乏症调查显示，这一特征在普什图族和乌兹别克族难民中最为常见（分别为15.8%和9.1%）。巴基斯坦普什图族中的患病率为7.0%，塔吉克族和土库曼族难民中的患病率分别为2.9%和2.1%。医院研究表明，普什图族中G-6-PD缺乏症的类型可能会引发严重的溶血性危机。在普什图族社区中，伯氨喹治疗存在潜在的致命副作用，且再次感染风险很高，这使得间日疟原虫的抗复发治疗政策过时。然而，恶性疟原虫疟疾的流行情况可能使在传播季节将伯氨喹作为一种杀配子体药物单剂量使用具有合理性。这些发现有必要修订该地区使用伯氨喹的建议。
