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[新生期仔猪骨髓红系细胞代谢及抗氧化系统各环节的变化]

[Changes in various links of metabolism and the antioxidant system in the bone marrow erythroid cells of the pig during the neonatal period].

作者信息

Antoniak H L

机构信息

Institute for Research in Animal Physiology and Biochemistry, Lviv, Ukraine.

出版信息

Ukr Biokhim Zh (1978). 1998 Sep-Oct;70(5):133-9.

Abstract

The age dynamics of activities of enzymes which catalysis several stages of metabolism (hexokinase, phosphofructokinase, pyruvate kinase, lactate dehydrogenase, 2,3-diphosphoglycerate mutase, glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and cytochrome oxidase) and antioxidant system (superoxide dismutase, glutathione peroxidase and glutathione reductase) was studied in the bone marrow erythroid cells of pig during the 10-day period after birth as well as in the cells of 30 days old animals. It was established that in the neonatal period of development the reorganization of energy metabolism in pig bone marrow erythrokaryocytes took place. It consisted in the intensification of oxidative processes and in a great measure was directed on the activation of 2,3-diphosphoglycerate mutase formation in the nature red cells. During the early period after birth the activation of antioxidant system in erythroid cells of pig bone marrow was observed.

摘要

研究了出生后10天内仔猪骨髓红细胞以及30日龄动物细胞中催化代谢多个阶段的酶(己糖激酶、磷酸果糖激酶、丙酮酸激酶、乳酸脱氢酶、2,3-二磷酸甘油酸变位酶、葡萄糖-6-磷酸脱氢酶、异柠檬酸脱氢酶和细胞色素氧化酶)和抗氧化系统(超氧化物歧化酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶)活性的年龄动态变化。结果表明,在仔猪发育的新生儿期,骨髓红细胞中的能量代谢发生了重组。这包括氧化过程的强化,并且在很大程度上旨在激活天然红细胞中2,3-二磷酸甘油酸变位酶的形成。在出生后的早期,观察到仔猪骨髓红细胞中抗氧化系统的激活。

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