Iwasaki H, Igarashi M, Yamauchi M, Namiki A
Department of Anaesthesiology, Sapporo Medical University School of Medicine, Japan.
Anaesthesia. 1995 Apr;50(4):361-2. doi: 10.1111/j.1365-2044.1995.tb04619.x.
A relationship between cardiac output and the onset time of neuromuscular blockade administered into a peripheral vein was evaluated in 41 adult patients. Anaesthesia was induced with midazolam and fentanyl and maintained with intermittent doses of fentanyl and 66% nitrous oxide in oxygen. After immobilisation of the forearm in a splint, the ulnar nerve in the other arm was stimulated supramaximally every 10 s and the adduction force of the thumb was recorded. The times from administration of vecuronium 0.08 mg.kg-1 to first and 95% depression of twitch response was 82.4 (18.0) s and 191.7 (33.5) s (mean, SD), respectively. A significant correlation between cardiac index and the onset time of blockade was observed. This study demonstrated that the rapidity of the onset of paralysis in the adductor pollicis muscle after vecuronium injection into a peripheral vein is clearly related to cardiac output.
在41例成年患者中评估了心输出量与经外周静脉给予神经肌肉阻滞剂起效时间之间的关系。采用咪达唑仑和芬太尼诱导麻醉，并用间断剂量的芬太尼和66%氧化亚氮-氧气混合气体维持麻醉。将前臂固定在夹板中后，每隔10秒对另一只手臂的尺神经进行超强刺激，并记录拇指内收力。给予维库溴铵0.08mg·kg-1至抽搐反应首次和95%抑制的时间分别为82.4（18.0）秒和191.7（33.5）秒（均值，标准差）。观察到心脏指数与阻滞起效时间之间存在显著相关性。本研究表明，经外周静脉注射维库溴铵后，拇内收肌麻痹起效的速度与心输出量明显相关。
