Gallou G, Ruelland A, Campion L, Allannic H, Legras B, Cloarec L
Laboratoire de biochimie A, CHU hôpital Sud, Rennes, France.
Ann Biol Clin (Paris). 1994;52(10):695-9.
Since oxidized LDL may play a role in the genesis of atheroma, which is the primary complication of non-insulin-dependent diabetes mellitus (NIDDM), we investigated whether the LDL of diabetic patients were more prone to oxidation than those of healthy controls. We therefore studied the susceptibility of LDL to oxidation by phenylhydrazine (LDL-PO) in NIDDM patients with or without macroangiopathy, and in controls. Results showed that the LDL of patients with macroangiopathy (n = 50) were more susceptible to oxidation than those of both NIDDM patients without vascular complications (n = 50) and controls (n = 50). In diabetic patients, there was a positive correlation between LDL-PO and the following parameters: total cholesterol, triglycerides, LDL cholesterol, apolipoprotein B. In contrast, there was no correlation between LDL-PO and the parameters of glycemic control (fasting glucose, HbAlc). After analyzing the composition of LDL, it appeared that LDL-PO values in diabetic patients were positively correlated with those of all LDL constituents. The increase in LDL-PO observed in the group of NIDDM patients with macroangiopathy could be a consequence of an increase in the LDL triglyceride content in these patients.
由于氧化型低密度脂蛋白（LDL）可能在动脉粥样硬化的发生过程中起作用，而动脉粥样硬化是非胰岛素依赖型糖尿病（NIDDM）的主要并发症，我们研究了糖尿病患者的LDL是否比健康对照者的LDL更容易被氧化。因此，我们研究了伴有或不伴有大血管病变的NIDDM患者以及对照者的LDL对苯肼氧化的敏感性（LDL-PO）。结果显示，有大血管病变的患者（n = 50）的LDL比无血管并发症的NIDDM患者（n = 50）以及对照者（n = 50）的LDL更容易被氧化。在糖尿病患者中，LDL-PO与以下参数呈正相关：总胆固醇、甘油三酯、LDL胆固醇、载脂蛋白B。相反，LDL-PO与血糖控制参数（空腹血糖、糖化血红蛋白）之间无相关性。分析LDL的组成后发现，糖尿病患者的LDL-PO值与所有LDL成分的值呈正相关。在伴有大血管病变的NIDDM患者组中观察到的LDL-PO升高可能是这些患者LDL甘油三酯含量增加的结果。
