Durlach V, Gillery P, Bertin E, Taupin J M, Grulet H, Gross A, Leutenegger M
Medical Clinic, Hopital Robert Debré, Reims, France.
Diabetes Metab. 1996 Oct;22(5):319-23.
Variations in serum Lp(a) concentrations were studied in a large population of non-insulin-dependent diabetic (NIDDM) patients in relation to long-term complications. Lp(a) concentrations were measured by immunonephelometry in 819 NIDDM subjects and compared with those of 128 controls. Correlations were investigated relative to plasma lipid and glycaemic parameters, body mass index (BMI) and macro- and microvascular complications. Mean absolute and relative variations of Lp(a) concentrations were studied in a subgroup of 245 patients over a one-year period. No significant differences were found between Lp(a) concentrations in NIDDM and control subjects. No relationship was evidenced with macrovascular and microvascular complications or glycaemic control. Mean relative Lp(a) variations were correlated with BMI and absolute and relative variations in triglyceridaemia. These results confirm the absence of any alterations of Lp(a) concentrations in a large cohort of NIDDM patients, either with or without micro- and macrovascular complications, but suggest a particular modulatory role for BMI and serum triglyceride variations.
在大量非胰岛素依赖型糖尿病（NIDDM）患者中研究了血清Lp(a)浓度的变化及其与长期并发症的关系。采用免疫比浊法测定了819名NIDDM患者的Lp(a)浓度，并与128名对照者的Lp(a)浓度进行比较。研究了Lp(a)浓度与血浆脂质、血糖参数、体重指数（BMI）以及大血管和微血管并发症之间的相关性。在一个由245名患者组成的亚组中，对其Lp(a)浓度在一年期间的平均绝对和相对变化进行了研究。未发现NIDDM患者与对照者之间Lp(a)浓度存在显著差异。未发现Lp(a)浓度与大血管和微血管并发症或血糖控制之间存在关联。Lp(a)的平均相对变化与BMI以及甘油三酯血症的绝对和相对变化相关。这些结果证实，在一大群NIDDM患者中，无论有无微血管和大血管并发症，Lp(a)浓度均无任何改变，但提示BMI和血清甘油三酯变化具有特殊的调节作用。
