Crabbe J C, Belknap J K
Research Service (151W), Department of Veterans Affairs Medical Center, Portland, OR 97201, USA.
Alcohol Alcohol Suppl. 1993;2:477-82.
Many studies with rodent models have illustrated the role of genetic factors in determining the severity of ethanol withdrawal. In studies using inbred mouse strains and mice selectively bred for drug sensitivity, a consistent finding has been that genotypes susceptible to alcohol withdrawal are also susceptible to withdrawal from other drugs with CNS depressant effects. A new method for rough genetic mapping of genes associated with withdrawal, quantitative trait loci (QTL) gene mapping, has recently been employed in the BXD RI recombinant inbred mouse series. Several QTLs are associated with alcohol withdrawal: One such QTL on Chromosome 1 is described. An area of Chromosome 2 contains a QTL marker for a gene affecting withdrawal from acute and chronic ethanol, nitrous oxide, and high-pressure neurological syndrome Type I clonic convulsions.
许多以啮齿动物模型进行的研究已经阐明了遗传因素在决定乙醇戒断严重程度方面的作用。在使用近交系小鼠品系以及针对药物敏感性进行选择性培育的小鼠的研究中，一个一致的发现是，易患酒精戒断的基因型也易患对具有中枢神经系统抑制作用的其他药物的戒断反应。一种用于与戒断相关基因的粗略遗传图谱绘制的新方法，即数量性状基因座（QTL）基因图谱绘制，最近已应用于BXD RI重组近交小鼠系列。有几个QTL与酒精戒断相关：描述了位于1号染色体上的一个此类QTL。2号染色体的一个区域包含一个QTL标记，该标记对应一个影响急性和慢性乙醇、一氧化二氮以及高压神经综合征I型阵挛性惊厥戒断反应的基因。
