脑内注射铁会逐渐降低纹状体多巴胺代谢。
Intranigral injected iron progressively reduces striatal dopamine metabolism.
作者信息
Wesemann W, Blaschke S, Solbach M, Grote C, Clement H W, Riederer P
机构信息
Department of Neurochemistry, Institute of Physiological Chemistry, Marburg, Federal Republic of Germany.
出版信息
J Neural Transm Park Dis Dement Sect. 1994;8(3):209-14. doi: 10.1007/BF02260941.
PMID:7748464
Abstract
The striatal dopamine metabolism of the rat was followed 1, 3, and 6 weeks after unilateral intranigral iron (III) (50- and 1.5 micrograms) application. For both concentrations a progredient decrease of extraneuronal 3.4-dihydroxyphenylacetic acid (DOPA) levels was observed in the ipsilateral striatum.
摘要
在单侧黑质内注射铁（III）（50微克和1.5微克）后1周、3周和6周，对大鼠纹状体多巴胺代谢情况进行了跟踪研究。对于这两种浓度，均观察到同侧纹状体内神经元外3,4-二羟基苯乙酸（DOPA）水平呈进行性下降。
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