小细胞肺癌的外科治疗

Surgical treatment of small cell lung cancer.

作者信息

Coolen L, Van den Eeckhout A, Deneffe G, Demedts M, Vansteenkiste J

机构信息

Department of Pneumology, University Hospital Gasthuisberg, University of Leuven, Belgium.

出版信息

Eur J Cardiothorac Surg. 1995;9(2):59-64. doi: 10.1016/s1010-7940(05)80018-1.

DOI:10.1016/s1010-7940(05)80018-1

PMID:7748573

Abstract

From 1970 till 1989, 30 patients underwent surgical resection for small cell lung cancer (SCLC). The 5-year survival in stage I patients was 31%, in stage II 17% and in stage III the projected 5-year survival was 9%. Among N2 patients there were only 25% survivors after 1 year and none after 2 years. The first group of 15 patients (1970-1979) received no adjuvant chemotherapy in contrast to the second group of 15 patients (1980-1989). The overall 5-year survival for the first group was 13% and the estimated 5-year survival for the second group was 27%. In stage I SCLC, the 5-year survival was 12% and 60%, respectively. These results confirm that surgery may lead to long-term survival in stage I and possibly stage II SCLC, with better prognosis in stage I when adjuvant chemotherapy is added.

摘要

1970年至1989年期间，30例患者接受了小细胞肺癌（SCLC）手术切除。I期患者的5年生存率为31%，II期为17%，III期预计5年生存率为9%。在N2期患者中，1年后仅有25%存活，2年后无存活者。第一组15例患者（1970 - 1979年）未接受辅助化疗，与之形成对比的是第二组15例患者（1980 - 1989年）。第一组的总体5年生存率为13%，第二组的预计5年生存率为27%。在I期SCLC中，5年生存率分别为12%和60%。这些结果证实，手术可能使I期以及可能的II期SCLC患者获得长期生存，添加辅助化疗时I期患者预后更佳。